What is Microdosing

Microdosing is the act of integrating sub-perceptual doses of psychedelics, such as psilocybin truffles or -mushrooms, into your weekly routine. The microdose is being used as a tool to assist in physical-, mental- and emotional wellbeing and personal growth.

Sub-perceptual means the effects are subtle but can have a noticeable influence on your life. Typically, individuals integrate sub-perceptual doses into their weekly routine.

Higher levels of creativity, more energy, increased focus, and improved relational skills are often reported. Some people microdose in order to treat depression or anxiety.

Our goal is to research if some of society's problems such as depression and addiction, can be remedied with the use of plant medicines. We do this by collecting anecdotal evidence from our members and seeing what personal growth is possible with the right intention and guidance.

Why Microdosing

Microdosing can be done for many different reasons and purposes: to feel more creativity or focus and clarity, to experience more solidarity with yourself or a partner. To get back in touch with your inner compass or simply to cultivate a more positive outlook on life. It cannot be definitely claimed yet that microdosing is actually effective on all of these reported points. This is being mapped out at this time.

It is recommended to stop microdosing after two months in order to experience your daily routine without this "tool" and to take time to integrate the experiences and insights before you start your next trial.

Measured Effects

  • Mood enhancement
  • Decreased stress
  • Emotional stability
  • Mindfulness, presence, and peace
  • Openness and self-forgiveness
  • Increased empathy and sociability
  • Conversational fluidity
  • Alleviation of persistent conditions such as depression, anxiety, ADD/ADHD, PTSD
  • Increased motivation (e.g. to make positive lifestyle changes)
  • Increased focus/productivity
  • Increased flow states
  • Clearer, more connected thinking
  • Improved memory
  • Enhanced senses
  • Enhanced appreciation for music, art, etc.
  • Increased creativity
  • Spontaneity
  • Easier meditation
  • Increased enjoyment of physical activity and everyday tasks
  • Relaxation and increased awareness of body
  • Enhanced athletic endurance
  • Increased energy overall (without anxiety or a subsequent crash)

  • Amplification of mood, positive or negative
  • Slight sedative effect

  • Possible manic states
  • Potentially increased neuroticism

  • Fatigue may develop (due to processing more impressions or living a more active life)
  • Some people experience mild nausea 
  • Tolerance has been reported when used every day
  • Dealing with changes in your consciousness and your sensitivity can be challenging

Note: Above listed effects listed aren’t meant to be definitively comprehensive. They may be subject to change as more reliable, more widely representative data becomes available.

Microdosing and depression chart.

Depression is the leading cause of disability worldwide, affecting more than 300 million people, according to the World Health Organization. 

Disorders related to anxiety and depression in combination with the guided microdosing research program

Depression can reduce life expectancies by an average of 10 years and may lead to suicide from which nearly 800,000 people die each year. There is an urgent need to identify and test novel treatments that may benefit people suffering from depression.

Psilocybin is one of the safest psychedelic substances to work with (especially when taking a microdose) as this chart shows

Our goal is to contribute to the collective well-being by researching the safety and efficacy of psilocybin as a possible treatment for depression and addiction.

Learn More

Psychedelic brainscan showing neural connections. Microdosing psilocybin influences and regulates the serotonin receptors

What happens in our brain after taking a microdose? 

Psychedelic substances that are effective in microdose act on the serotonin receptors (5-hydroxytryptamine or 5-HT). This system regulates our thinking and the way we learn. Our nervous system contains all kinds of unique serotonin receptors, which collectively regulate a variety of functions, ranging from our mood to our bowel movements. The receptors primarily responsible for our learning, memory, and thinking are the 5-HT1A, 5-HT2A, 5-HT3, 5-HT4, 5-HT6, and 5-HT7 receptors, and 5-HT2 is the one where psychedelics interact the most.This explains the cognitive boost caused by the microdosing of psilocybin. 

[Source: Serotonin Receptors in Cognitive Behaviors. (1997) ]

News and Media

The iceberg of the subconscious. Reprogram your mind. Expand your perspective. Vistaplus microdose research foundation

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