Microdosing Research

Microdosing psilocybin mushrooms research vistaplus microdosing truffles questionnaire study microdoseren vista+ depression

Relatively little physiological research has been done into the effects of microdoses and psychedelics.
Dr. Robin Carhart-Harris of Imperial College London is doing groundbreaking research where subjects were put in an MRI while 'tripping'. Such experimentation shows that blood flow to the Default Mode Network (DMN) is inhibited during a trip. Thus also slightly during a microdose. 

The DMN controls our self-image and the way in which we are 'programmed'. So both the ego (self-image) and the connections which we always make (programming) are both pinched a bit. This means that you are less strict with yourself and you feel more connected with your environment (self-image) and easily make new connections and/or have insights (programming). 

MRI brain scan Dr. Carhart-Harris DMN psychedelic psilocybin microdosing research vista+

In your DMN your ego lives. Also many of your standard (operating) procedures are stored there. Because the suppressed blood flow to the DMN, your ego gets railed-in taking the microdose with the result that you are more loving to yourself and less demanding. Similarly, because your standard (operating) procedures are disrupted, you are able to break out of your tunnel vision and see different options going forward. We think this is what people refer to as 'insights'. And these allow you to break established habitual patterns and create new patterns for yourself.

Brainscan showing a normal and psilocybin influenced brain. Default mode network can be accessed with psilocybine microdose

By living a conscious intention during your microdose period, you are more able to steer your insights, and benefit from a 'squeezed' ego. It is important to actively reflect on your intention during the months of microdosing, helping you to integrate your insights and new found perception of self. So that when you stop the microdosing period, you can still reap the benefits in the long term.

VistaPlus+ Results

VistaPlus participants experienced +7% more 'happiness' on average within a time frame of three months after starting our program. Concentration increases on an average of +13% after two weeks, and +15% after three months. Feelings of insecurity reduced with -15% after only two weeks of microdosing. Our participants felt +5% more in touch with their feelings after two weeks, +11% after a month and +16% after three months {2019}.

Note: Above stated results may be subject to change as more reliable, more widely representative data becomes available.

Microdosing Placebo Study

Beckley foundation Imperial College London Double blinding placebo study Balazs Szigeti Vistaplus microdosing research

Self Double Blinding Placebo Study

This innovative study led by Dr. Balázs Szigeti and Dr. David Erritzoe of Imperial College London, in partnership with Amanda Feilding of the Beckley Foundation, allows microdosers to implement placebo control during self-experimentation.

The central hypothesis of this study is that microdosing can increase psychological well-being and cognitive functioning in healthy subjects. In parallel, is being examined whether microdosing can induce any negative effects such as anxiety.

We are excited to have contributed to this groundbreaking research in collaboration with Balázs, by guiding subjects in the process of microdosing with psychedelics.

You can read more about Balasz's self-blinding placebo study here. 

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Studies with Healthy Adults

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       James Fadiman ,Sophia Korb Published online: 29 Mar 2019


Studies on Depression

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       First Published August 27, 2020 Review Article https://doi.org/10.1177/2045125320950567



Studies on Addiction

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If the doors of perception were cleansed 
every thing would appear to man as it is, 

- William Blake